Mediprofen

STATEMENT OF THE ACTIVE SUBSTANCE (S) AND OTHER INGREDIENTS

1 ml of solution for injection contains:
Active substance: Ketoprofen 100 mg
Excipients: Benzyl alcohol 10 mg, L-arginine, citric acid monohydrate and water for injections.

INDICATIONS

Mediprofen contains a non steroidal antiinflamatory ketoporfen drug with pronounced antiinflamatory, antyipyretic and analgesic effects.  cattle, as an adjuvant therapy of puerparal paresis, hyperthermia due to bacterial infections of the respiratory tract (along with appropriate antimicrobial therapy), adjuvant therapy of acute clinical mastitis, including the endotoxic mastitis in combination with antimicrobial drugs, pain relief and edema of the udder after calving Pigs ketoprofen alleviates hyperpyrexia and respiratory disorders, due to bacterial or viral infections of the respiratory system, in conjunction with antimicrobial therapy. It is used also in supportive therapy of MMA syndrome along with appropriate antimicrobial therapy.

CONTRAINDICATIONS

• Do not use in cattle and pigs with previously demonstrated hypersensitivity to ketoprofen.

• Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concomitantly or 24 hours before /after the application of a Mediprofen.

• Do not use in animals with impaired function of heart, liver or kidney, and in those with suspected gastrointestinal ulceration and bleeding.

• Do not use in animals with a history of blood dyscrasia and known hypersensitivity to ketoprofen.

• The drug should not be used in dehydrated, hypovolaemic or hypotensive animals, because it might increase the risk of nephrotoxicity.

ADVERSE REACTIONS

As with other nonsteroidal anti-inflammatory drugs, ketoprofen can cause gastric and renal intolerance as a result of inhibition of prostaglandin synthesis in some animals. Allergic reactions are extremely rare but possible and if occurred, the therapy should be discontinued. Local irritation at the injection site is possible after intramuscular administration of the drug.

TARGET SPECIES

Cattle and pigs.

DOSAGE FOR EACH SPECIES, ROUTES AND METHOD OF ADMINSITRATION

Cattle: The recommended dose of ketoprofen is 3mg / kg body weight, or 1 ml of Mediprofen per 33kg body weight, as a deep intramuscular injection, once a day for three days.
Pigs: The recommended dose of ketoprofen is 3mg / kg body weight or 1 ml of Mediprofen per 33kg body weight, as a deep intramuscular injection, Single daily for three days.

ADVICE ON CORRECT ADMINISTRATION

Take care to avoid intraarterial application. Do not exceed the recommended dose and duration of therapy. Administer maximum 10ml of the drug per injection site. Use of this drug in animals less than 6 weeks or in very old animals may result in additional risk of causing adverse effects. If the application of the drug is still necessary, reduce the dose and carefully monitor the patient

WITHDRAWAL PERIOD

Cattle: Meat and offal: 4 days, milk 0 days
Pigs: Meat and offal: 4 days

SPECIAL STORAGE PRECAUTIONS

Keep out from the reach of children
Store in original package at temperature of 25oC,
Shelf life: 3 years
Shelf life after first opening 28 days

SPECIAL WARNINGS

• Take care to avoid intra-arterial application.
• Do not exceed the recommended dose and duration of therapy.
• Administer maximum of 10ml of the drug per injection site.
• Special precautions to be taken by the person administering the veterinary medicinal product to animals If the drug comes into contact with skin or mucous membranes (or eyes) immediately rinse with running water.
• Do not eat, drink or smoke while manipulation this drug. Take care to avoid self injecting. If this occurs, ask for a medical attention.

SPECIAL PRECAUTIONS FOR THE DIPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS IF ANY

Any unused veterinary medicinal product or waste materials derived form such veterinary medicinal product should be disposed in accordance with local requirements.

OTHER INFORMATION

Packaging units: bottle 1x 100 ml in cardboard box
Prescription only medicine